Alginate Alleviates Dextran Sulfate Sodium-Induced Colitis by Promoting Bifidobacterium animalis and Intestinal Hyodeoxycholic Acid Synthesis in Mice

Alginate Alleviates Dextran Sulfate Sodium-Induced Colitis by Promoting Bifidobacterium animalis and Intestinal Hyodeoxycholic Acid Synthesis in Mice

ABSTRACT Alginate (ALG) is known to alleviate intestinal inflammation in inflammatory bowel disease, but its mechanism of action remains elusive. In the present study, we studied the involvement of the intestinal microbiota and bile acid (BA) metabolism in ALG-mediated anti-inflammatory effects in m...

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Bibliographic Details
Main Authors: Yu Pi, Xiangyu Zhang, Yujun Wu, Zhenyu Wang, Yu Bai, Xiaoyi Liu, Dandan Han, Jinbiao Zhao, Isabel Tobin, Jiangchao Zhao, Guolong Zhang, Junjun Wang
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
alginate
bile acid
hyodeoxycholic acid
inflammatory bowel disease
microbiome
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02979-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02979-22

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