The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases

Barley β-d-glucan glucohydrolase is a glycoside hydrolase family 3 (GH3) enzyme critical for growth and development. Here the authors carryout mutagenesis, structural analyses and multi-scale molecular dynamics to examine the binding and conformational behaviour of several β-d-glucosides during the...

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Bibliographic Details
Main Authors: Sukanya Luang, Xavier Fernández-Luengo, Alba Nin-Hill, Victor A. Streltsov, Julian G. Schwerdt, Santiago Alonso-Gil, James R. Ketudat Cairns, Stéphanie Pradeau, Sébastien Fort, Jean-Didier Maréchal, Laura Masgrau, Carme Rovira, Maria Hrmova
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33180-5