Comparative Analysis of Enzymatic Transglycosylation Using <i>E.</i> <i>coli</i> Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2′-Deoxyribonucleosides from Ribonucleosides

Comparative Analysis of Enzymatic Transglycosylation Using <i>E.</i> <i>coli</i> Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2′-Deoxyribonucleosides from Ribonucleosides

A comparative analysis of the transglycosylation conditions catalyzed by <i>E. coli</i> nucleoside phosphorylases, leading to the formation of 2′-deoxynucleosides, was performed. We demonstrated that maximal yields of 2′-deoxynucleosides, especially modified, can be achieved under small...

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Bibliographic Details
Main Authors: Mikhail S. Drenichev, Vladimir E. Oslovsky, Anastasia A. Zenchenko, Claudia V. Danilova, Mikhail A. Varga, Roman S. Esipov, Dmitry D. Lykoshin, Cyril S. Alexeev
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
7-methyl-2′deoxyguanosine
nucleoside phosphorylase
enzymes
transglycosylation
biologically active nucleosides
fluorine
Online Access:https://www.mdpi.com/1422-0067/23/5/2795

Internet

https://www.mdpi.com/1422-0067/23/5/2795

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