Design, Synthesis and Antimicrobial Evaluation of New <i>N</i>-(1-Hydroxy-1,3-dihydrobenzo[<i>c</i>][1,2]oxaborol-6-yl)(hetero)aryl-2-carboxamides as Potential Inhibitors of Mycobacterial Leucyl-tRNA Synthetase

Design, Synthesis and Antimicrobial Evaluation of New <i>N</i>-(1-Hydroxy-1,3-dihydrobenzo[<i>c</i>][1,2]oxaborol-6-yl)(hetero)aryl-2-carboxamides as Potential Inhibitors of Mycobacterial Leucyl-tRNA Synthetase

Tuberculosis remains a serious killer among infectious diseases due to its incidence, mortality, and occurrence of resistant mycobacterial strains. The challenge to discover new antimycobacterial agents forced us to prepare a series of <i>N</i>-(1-hydroxy-1,3-dihydrobenzo[<i>c</...

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Bibliographic Details
Main Authors: Petr Šlechta, Adam Anthony Needle, Ondřej Jand’ourek, Pavla Paterová, Klára Konečná, Pavel Bárta, Jiří Kuneš, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
antimicrobial
antimycobacterial
benzoxaborole
cytotoxicity
molecular docking
multidrug-resistant tuberculosis
Online Access:https://www.mdpi.com/1422-0067/24/3/2951

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https://www.mdpi.com/1422-0067/24/3/2951

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