Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy

Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy

Abstract Current treatments for T cell malignancies encounter issues of disease relapse and off-target toxicity. Using T cell receptor (TCR)Vβ2 as a model, here we demonstrate the rapid generation of an off-the-shelf allogeneic chimeric antigen receptor (CAR)-T platform targeting the clone-specific...

Full description

Bibliographic Details
Main Authors: Jingjing Ren, Xiaofeng Liao, Julia M. Lewis, Jungsoo Chang, Rihao Qu, Kacie R. Carlson, Francine Foss, Michael Girardi
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44786-2

Internet

https://doi.org/10.1038/s41467-024-44786-2

Similar Items