Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus

Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus

ABSTRACTEpstein-Barr virus (EBV) is a ubiquitous human virus that promotes B-cell activation and maturation through expression of latency proteins and non-coding RNAs. In this study, we provide evidence that EBV mimics the molecular phenotype of germinal center (GC) B cells. EBV infection of primary...

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Bibliographic Details
Main Authors: Joanne Dai, Elliott D. SoRelle, Emma Heckenberg, Lingyun Song, Jana M. Cable, Gregory E. Crawford, Micah A. Luftig
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
B-cell
germinal center
EBV
antiapoptosis
chromatin
Online Access:https://journals.asm.org/doi/10.1128/mbio.02444-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02444-23

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