Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage.

Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage.

During bleeding the skin is subjected to oxidative insults from free heme and radicals, generated from extracellular hemoglobin. The lipocalin α(1)-microglobulin (A1M) was recently shown to have reductase properties, reducing heme-proteins and other substrates, and to scavenge heme and radicals. We...

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Bibliographic Details
Main Authors: Magnus G Olsson, Maria Allhorn, Jörgen Larsson, Martin Cederlund, Katarina Lundqvist, Artur Schmidtchen, Ole E Sørensen, Matthias Mörgelin, Bo Akerström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3214066?pdf=render

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http://europepmc.org/articles/PMC3214066?pdf=render

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