The Antimalarial Drug Artesunate Mediates Selective Cytotoxicity by Upregulating HO-1 in Melanoma Cells

The Antimalarial Drug Artesunate Mediates Selective Cytotoxicity by Upregulating HO-1 in Melanoma Cells

Despite great efforts to develop new therapeutic strategies to combat melanoma, the prognosis remains rather poor. Artesunate (ART) is an antimalarial drug displaying anti-cancer effects in vitro and in vivo. In this in vitro study, we investigated the selectivity of ART on melanoma cells. Furthermo...

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Bibliographic Details
Main Authors: Finn Jochims, Rebecca Strohm, Claudia von Montfort, Chantal-Kristin Wenzel, Niklas Klahm, Arun Kumar Kondadi, Wilhelm Stahl, Andreas S. Reichert, Peter Brenneisen
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomedicines
Subjects:
melanoma
cancer therapy
drug repurposing
oxidative stress
natural compound
artesunate
Online Access:https://www.mdpi.com/2227-9059/11/9/2393

Internet

https://www.mdpi.com/2227-9059/11/9/2393

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