Impairment of PMP22 transgenic Schwann cells differentiation in culture: implications for Charcot-Marie-Tooth type 1A disease

Impairment of PMP22 transgenic Schwann cells differentiation in culture: implications for Charcot-Marie-Tooth type 1A disease

Charcot-Marie-Tooth type 1A (CMT1A) is a hereditary demyelinating neuropathy due to an increased genetic dosage of the peripheral myelin protein 22 (PMP22). The mechanisms leading from PMP22 overexpression to impairment of myelination are still unclear. We evaluated expression and processing of PMP2...

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Bibliografski detalji
Glavni autori: Lucilla Nobbio, Tiziana Vigo, Michele Abbruzzese, Giovanni Levi, Claudio Brancolini, Stefano Mantero, Marina Grandis, Luana Benedetti, Gianluigi Mancardi, Angelo Schenone
Format: Članak
Jezik:English
Izdano: Elsevier 2004-06-01
Serija:Neurobiology of Disease
Teme:
CMT1A
Hereditary neuropathy
PMP22
Schwann cell
Axon
Motility
Online pristup:http://www.sciencedirect.com/science/article/pii/S0969996104000415

Internet

http://www.sciencedirect.com/science/article/pii/S0969996104000415

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