Impairment of PMP22 transgenic Schwann cells differentiation in culture: implications for Charcot-Marie-Tooth type 1A disease

Impairment of PMP22 transgenic Schwann cells differentiation in culture: implications for Charcot-Marie-Tooth type 1A disease

Charcot-Marie-Tooth type 1A (CMT1A) is a hereditary demyelinating neuropathy due to an increased genetic dosage of the peripheral myelin protein 22 (PMP22). The mechanisms leading from PMP22 overexpression to impairment of myelination are still unclear. We evaluated expression and processing of PMP2...

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Bibliographic Details
Main Authors: Lucilla Nobbio, Tiziana Vigo, Michele Abbruzzese, Giovanni Levi, Claudio Brancolini, Stefano Mantero, Marina Grandis, Luana Benedetti, Gianluigi Mancardi, Angelo Schenone
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Neurobiology of Disease
Subjects:
CMT1A
Hereditary neuropathy
PMP22
Schwann cell
Axon
Motility
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000415

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