A pref-1-controlled non-inflammatory mechanism of insulin resistance

A pref-1-controlled non-inflammatory mechanism of insulin resistance

Summary: While insulin resistance (IR) is associated with inflammation in white adipose tissue, we report a non-inflammatory adipose mechanism of high fat-induced IR mediated by loss of Pref-1. Pref-1, released from adipose Pref-1+ cells with characteristics of M2 macrophages, endothelial cells or p...

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Bibliographic Details
Main Authors: Yiheng Huang, Donghong Cui, Liujun Chen, Haibin Tong, Hong Wu, Grace K. Muller, Yadan Qi, Shuxia Wang, Jinjie Xu, Xiang Gao, Kathleen E. Fifield, Lingyan Wang, Zhengyuan Xia, Jacqueline L. Vanderluit, Suixin Liu, Lin Leng, Guang Sun, John McGuire, Lawrence H. Young, Richard Bucala, Dake Qi
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Molecular biology
Immunology
Cell biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010003

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http://www.sciencedirect.com/science/article/pii/S2589004223010003

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