Pharmacokinetics of Lixisenatide, a GLP-1 Receptor Agonist, Determined by a Novel Liquid Chromatography–Tandem Mass Spectrometry Analysis in Rats

Pharmacokinetics of Lixisenatide, a GLP-1 Receptor Agonist, Determined by a Novel Liquid Chromatography–Tandem Mass Spectrometry Analysis in Rats

Because of its greater binding affinity and longer half-life than native glucagon-like peptide-1 (GLP-1), the GLP-1 receptor agonist lixisenatide is commonly used to treat type 2 diabetes mellitus. This study aimed to establish a simple and robust liquid chromatography–tandem mass spectrometry (LC–M...

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Bibliographic Details
Main Authors: Hyeon Seok Oh, Eun Ji Park, Tae Suk Lee, Yejin An, Tae Hwan Kim, Soyoung Shin, Beom Soo Shin
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Separations
Subjects:
type 2 diabetes
lixisenatide
LC–MS/MS
pharmacokinetics
GLP-1 receptor agonists
Online Access:https://www.mdpi.com/2297-8739/10/5/282

Internet

https://www.mdpi.com/2297-8739/10/5/282

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