Designer Leptin Receptor Antagonist Allo-Aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models

Designer Leptin Receptor Antagonist Allo-Aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models

Experimental and clinical data suggest that pro-angiogenic, pro-inflammatory and mitogenic cytokine leptin can be implicated in ocular neovascularization and other eye pathologies. At least in part, leptin action appears to be mediated through functional interplay with vascular endothelial growth fa...

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Bibliographic Details
Main Authors: Roberta Coroniti, Rafal Farjo, Didier J Nuno, Laszlo Otvos, Laura Scolaro, Eva Surmacz
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Leptin
VEGF
Peptide drug
ObR antagonist
ocular neoangiogenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00067/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00067/full

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