Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers

Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers

Show other versions (1)

Epidermal growth factor receptor (EGFR) is overexpressed in various cancers, including non-small cell lung cancer (NSCLC), and in some somatic cells at a limited level, rendering it an attractive antitumor target. In this study, we engineered chimeric antigen receptor (CAR)-T cells using the piggyBa...

Full description

Bibliographic Details
Main Authors: Thanyavi Chinsuwan, Koichi Hirabayashi, Shuji Mishima, Aiko Hasegawa, Miyuki Tanaka, Hidemi Mochizuki, Akihito Shimoi, Takashi Murakami, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
cancer immunotherapy
CAR-T
EGFR
NSCLC
non-human primate
piggyBac
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000724

Internet

http://www.sciencedirect.com/science/article/pii/S2372770523000724

Similar Items