KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1

KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1

Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that negatively regulates anti-tumor immunity. Recent reports indicate that anti-cancer treatments, such as radiation therapy, increase PD-L1 expression on the surface of tumor cells. We previously reported that the nuclear transport...

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Bibliographic Details
Main Authors: Hironori Yoshino, Yoshiaki Sato, Manabu Nakano
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Current Issues in Molecular Biology
Subjects:
karyopherin-β1
ionizing radiation
programmed death-ligand 1
interferon regulatory factor 1
Online Access:https://www.mdpi.com/1467-3045/43/1/13

Internet

https://www.mdpi.com/1467-3045/43/1/13

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