MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

Abstract Background The involvement of non-neuronal cells and the cells of innate immunity has been attributed to the initiation and progression of ALS. TDP-43 pathology is observed in a broad spectrum of ALS cases and is one of the most commonly shared pathologies. The potential involvement of the...

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Bibliographic Details
Main Authors: Javier H. Jara, Mukesh Gautam, Nuran Kocak, Edward F. Xie, Qinwen Mao, Eileen H. Bigio, P. Hande Özdinler
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Neuroinflammation
Subjects:
Upper motor neurons
Microglia
MCP1-CCR2 axis
TDP-43
Online Access:http://link.springer.com/article/10.1186/s12974-019-1589-y

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http://link.springer.com/article/10.1186/s12974-019-1589-y

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