Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?

Neutrophils are innate immune cells with important roles in antimicrobial defense. However, impaired or dysregulated neutrophil function can result in host tissue damage, loss of homeostasis, hyperinflammation or pathological immunosuppression. A central link between neutrophil activation and immune...

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Bibliographic Details
Main Authors: Ondřej Vymazal, Kamila Bendíčková, Marco De Zuani, Marcela Vlková, Marcela Hortová-Kohoutková, Jan Frič
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
immunosuppression
calcineurin inbibitors
neutrophil (PMN) function
sepsis
NFAT signaling
pattern recognition receptor (PRR)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.770515/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.770515/full

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