Deep generative neural network for accurate drug response imputation
Drug response in cancer patients vary dramatically due to inter- and intra-tumor heterogeneity and transcriptome context plays a significant role in shaping the actual treatment outcome. Here, the authors develop a deep variational autoencoder model to compress gene signatures into latent vectors an...
| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Nature Portfolio
2021-03-01
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| Colecção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-021-21997-5 |