Lithium: effects in animal models of vanishing white matter are not promising

Lithium: effects in animal models of vanishing white matter are not promising

Vanishing white matter (VWM) is a devastating autosomal recessive leukodystrophy, resulting in neurological deterioration and premature death, and without curative treatment. Pathogenic hypomorphic variants in subunits of the eukaryotic initiation factor 2B (eIF2B) cause VWM. eIF2B is required for r...

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Bibliographic Details
Main Authors: Diede Witkamp, Ellen Oudejans, Leoni Hoogterp, Gino V. Hu-A-Ng, Kathryn A. Glaittli, Tamara J. Stevenson, Marleen Huijsmans, Truus E. M. Abbink, Marjo S. van der Knaap, Joshua L. Bonkowsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Neuroscience
Subjects:
lithium
vanishing white matter
integrated stress response
GSK3β
ATF4
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1275744/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2024.1275744/full

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