TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure. As current 'shock' agents failed to efficiently reactivate the latent reservoir, it is important to discover new targets for developing mo...

Full description

Bibliographic Details
Main Authors: Xiancai Ma, Tao Yang, Yuewen Luo, Liyang Wu, Yawen Jiang, Zheng Song, Ting Pan, Bingfeng Liu, Guangyan Liu, Jun Liu, Fei Yu, Zhangping He, Wanying Zhang, Jinyu Yang, Liting Liang, Yuanjun Guan, Xu Zhang, Linghua Li, Weiping Cai, Xiaoping Tang, Song Gao, Kai Deng, Hui Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
HIV-1 Latency
SUMOylation
promoter-proximal pausing
latency-reversing agents
P-TEFb
TRIM28
Online Access:https://elifesciences.org/articles/42426

Internet

https://elifesciences.org/articles/42426

Similar Items