Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies. Mass spectrometry studies indicate that tau acetylation sites cluster within the microtubule-binding region (MTBR), a region that is hi...

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Bibliographic Details
Main Authors: Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5176320?pdf=render

Internet

http://europepmc.org/articles/PMC5176320?pdf=render

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