Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in flatworm parasites and a promising pharmacolo...

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Bibliographic Details
Main Authors: Vivian Pasquet, Hugo Bisio, Gloria V. López, Laura Romanelli-Cedrez, Mariana Bonilla, Jenny Saldaña, Gustavo Salinas
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
thioredoxin reductase
glutathione reductase
thioredoxin glutathione reductase
oxadiazole N-oxide
Mesocestoides
tapeworms
Online Access:http://www.mdpi.com/1420-3049/20/7/11793

Internet

http://www.mdpi.com/1420-3049/20/7/11793

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