Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus)

Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus)

Morphology and function of the dorsolateral prefrontal cortex (dlPFC), and corresponding working memory performance, are affected early in the aging process, but nearly half of aged individuals are spared of working memory deficits. Translationally relevant model systems are critical for determining...

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Bibliographic Details
Main Authors: Courtney Glavis-Bloom, Casey R. Vanderlip, Sammy Weiser Novak, Masaaki Kuwajima, Lyndsey Kirk, Kristen M. Harris, Uri Manor, John H. Reynolds
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
marmoset (Callithrix jacchus)
working memory
ultrastructural size principle
aging
non-human primate (NHP)
electron microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1146245/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1146245/full

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