Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

Human mtDNA contains three promoters, suggesting a need for differential expression of the mitochondrial genome. Studies of mitochondrial transcription have used a reductionist approach, perhaps masking differential regulation. Here we evaluate transcription from light-strand (LSP) and heavy-strand...

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Bibliographic Details
Main Authors: Akira Uchida, Divakaran Murugesapillai, Markus Kastner, Yao Wang, Maria F Lodeiro, Shaan Prabhakar, Guinevere V Oliver, Jamie J Arnold, L James Maher III, Mark C Williams, Craig E Cameron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
mitochondria
transcription
mitochondrial DNA
atomic force microscopy
TFAM
hypervariable region
Online Access:https://elifesciences.org/articles/27283

Internet

https://elifesciences.org/articles/27283

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