Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis

Abstract Chondrosarcoma is a malignancy of soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is critical for neuronal cell growth, apoptosis, and differentiation, and also appears to promote the progression and metastasis of several different...

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Bibliographic Details
Main Authors: Huey-En Tzeng, Syuan-Ling Lin, Louis Anoop Thadevoos, Ming-Yu Lien, Wei-Hung Yang, Chih-Yuan Ko, Chih-Yang Lin, Yu-Wen Huang, Ju-Fang Liu, Yi-Chin Fong, Hsien-Te Chen, Chih-Hsin Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04392-2