Activation of Serum/Glucocorticoid Regulated Kinase 1/Nuclear Factor-κB Pathway Are Correlated with Low Sensitivity to Bortezomib and Ixazomib in Resistant Multiple Myeloma Cells

Activation of Serum/Glucocorticoid Regulated Kinase 1/Nuclear Factor-κB Pathway Are Correlated with Low Sensitivity to Bortezomib and Ixazomib in Resistant Multiple Myeloma Cells

Multiple myeloma (MM) is an incurable malignancy often associated with primary and acquired resistance to therapeutic agents, such as proteasome inhibitors. However, the mechanisms underlying the proteasome inhibitor resistance are poorly understood. Here, we elucidate the mechanism of primary resis...

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Bibliographic Details
Main Authors: Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Shiori Seki, Yoshika Tomonari, Shoutaro Koizumi, Miki Nagatakiya, Mai Katsuyama, Yuuta Yamamoto, Katsumasa Tsurushima, Toshihiko Ishizaka, Shozo Nishida
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomedicines
Subjects:
multiple myeloma
bortezomib
ixazomib
SGK1
nuclear factor (NF)-κB
low sensitivity
Online Access:https://www.mdpi.com/2227-9059/9/1/33

Internet

https://www.mdpi.com/2227-9059/9/1/33

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