NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells

NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells

Abstract Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand cross-links (ICLs), which block replication, transcription, and linear repair pathways by preventing DNA strand separation and trigger apo...

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Bibliographic Details
Main Authors: Umit Aliyaskarova, Yeldar Baiken, Flore Renaud, Sophie Couve, Alexei F. Kisselev, Murat Saparbaev, Regina Groisman
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-32186-3

Internet

https://doi.org/10.1038/s41598-023-32186-3

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