Insulin Stimulates Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Insulin Stimulates Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

We examined the effects of insulin on tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells (MBMECs). Treatment of MBMECs with insulin increased the intracellular BH4 content in a time- and concentration-dependent manner. The insulin-induced increase in BH4 content was i...

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Bibliographic Details
Main Authors: Ishi Masakazu, Shimizu Shunichi, Nagai Tsutomu, Kiuchi Yuji, Yamamoto Toshinori
Format: Article
Language:English
Published: De Gruyter 1999-11-01
Series:Pteridines
Subjects:
tetrahydrobiopterin
insulin
endothelial cell
Online Access:https://doi.org/10.1515/pteridines.1999.10.4.213

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https://doi.org/10.1515/pteridines.1999.10.4.213

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