Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells

Summary: Leukemic-stem-cell-specific targeting may improve the survival of patients with acute myeloid leukemia (AML) by avoiding the ablative effects of standard regimens on normal hematopoiesis. Herein, we perform an unbiased screening of compounds targeting cell surface proteins and identify clin...

Full description

Bibliographic Details
Main Authors: Chen Wang, Ravi Nistala, Min Cao, Yi Pan, Madelaine Behrens, Donald Doll, Richard D. Hammer, Puja Nistala, Hui-Ming Chang, Edward T.H. Yeh, XunLei Kang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300116X