Design, synthesis and SAR studies of novel tacrine derivatives as potent cholinesterase inhibitors
A series of tacrine-2-amide derivatives were synthesized and biologically evaluated for their acetylcholinesterase (AChE) inhibition studies. All synthesized compounds showed a good potency less than 100 nM. Of 11 analogues compounds 7b, 8a and 8c were found to exhibit good potency of 23.66 nM, 20...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417422000668 |