Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.

Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.

HIV-1 transmission is associated with a severe bottleneck in which a limited number of variants from a pool of genetically diverse quasispecies establishes infection. The IAVI protocol C cohort of discordant couples, female sex workers, other heterosexuals and men who have sex with men (MSM) present...

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Bibliographic Details
Main Authors: Gladys N Macharia, Ling Yue, Ecco Staller, Dario Dilernia, Daniel Wilkins, Heeyah Song, Edward McGowan, Deborah King, Pat Fast, Nesrina Imami, Matthew A Price, Eduard J Sanders, Eric Hunter, Jill Gilmour
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008853

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https://doi.org/10.1371/journal.ppat.1008853

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