ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

The yeast homologs of the ATM and ATR DNA damage response kinases play key roles in telomerase-mediated telomere maintenance, but the role of ATM/ATR in the mammalian telomerase pathway has been less clear. Here, we demonstrate the requirement for ATM and ATR in the localization of telomerase to tel...

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Main Authors: Adrian S. Tong, J. Lewis Stern, Agnel Sfeir, Melissa Kartawinata, Titia de Lange, Xu-Dong Zhu, Tracy M. Bryan
格式: 文件
语言:English
出版: Elsevier 2015-11-01
丛编:Cell Reports
在线阅读:http://www.sciencedirect.com/science/article/pii/S2211124715012115