Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy

Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy

Abstract Background Glioblastoma multiforme (GBM) is an incurable tumor, with a median survival rate of only 14–15 months. Along with heterogeneity and unregulated growth, a central matter in dealing with GBMs is cell invasiveness. Thus, improving prognosis requires finding new agents to inhibit key...

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Bibliographic Details
Main Authors: Nadia Trivieri, Alberto Visioli, Gandino Mencarelli, Maria Grazia Cariglia, Laura Marongiu, Riccardo Pracella, Fabrizio Giani, Amata Amy Soriano, Chiara Barile, Laura Cajola, Massimiliano Copetti, Orazio Palumbo, Federico Legnani, Francesco DiMeco, Leonardo Gorgoglione, Angelo L. Vescovi, Elena Binda
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioblastoma
Mitogen-independence
GBM cancer stem cells (GSCs)
GSCs biology and biomarkers
Anti-GSCs patient-tailored strategies
Online Access:https://doi.org/10.1186/s13046-022-02333-1

Internet

https://doi.org/10.1186/s13046-022-02333-1

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