Aberrant δPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease

Aberrant δPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease

Protein kinase C (PKC) was suggested to play a role in the pathology of amyotrophic lateral sclerosis (ALS) patients. Activation of PKC delta (δPKC) modulates mitochondrially induced apoptosis. The goal of the present study was to define whether δPKC activation occurs in Wobbler mouse spinal cord (a...

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Bibliographic Details
Main Authors: Kunjan R. Dave, Ami P. Raval, Jesús Purroy, Ilias G. Kirkinezos, Carlos T. Moraes, Walter G. Bradley, Miguel A. Pérez-Pinzón
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Neuronal death
Apoptosis
Cytochrome c
Neurological disorders
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001950

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http://www.sciencedirect.com/science/article/pii/S0969996104001950

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