Genetic and Functional Differences between Duplicated Zebrafish Genes for Human <i>SCN1A</i>

There are currently seven different zebrafish strains that model Dravet Syndrome, a severe childhood form of epilepsy. These models are based on a set of duplicated genes, <i>scn1laa</i> and <i>scn1lab</i>, which are the homologs for human <i>SCN1A</i>. Disrupting...

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Bibliographic Details
Main Authors: Wout J. Weuring, Jos W. Hoekman, Kees P. J. Braun, Bobby P. C. Koeleman
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/3/454