Targeting the inward rectifier potassium channel 5.1 in thyroid cancer: artificial intelligence-facilitated molecular docking for drug discovery

Targeting the inward rectifier potassium channel 5.1 in thyroid cancer: artificial intelligence-facilitated molecular docking for drug discovery

Abstract Background Recurrent and metastatic thyroid cancer is more invasive and can transform to dedifferentiated thyroid cancer, thus leading to a severe decline in the 10-year survival. The thyroid-stimulating hormone receptor (TSHR) plays an important role in differentiation process. We aim to f...

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Bibliographic Details
Main Authors: Xue Yang, Yonglin Wu, Shaojie Xu, Hanning Li, Chengcheng Peng, Xiaoqing Cui, Deenraj Kush Dhoomun, Ge Wang, Tao Xu, Menglu Dong, Xingrui Li, Yaying Du
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Endocrine Disorders
Subjects:
Differentiated papillary thyroid cancer
Thyroid-stimulating hormone receptor
Artificial intelligence
Deep docking
Computer-aided drug discovery
KCNJ16/Kir5.1
Online Access:https://doi.org/10.1186/s12902-023-01360-z

Internet

https://doi.org/10.1186/s12902-023-01360-z

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