Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity

Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity

Abstract Homocysteine (Hcy), produced physiologically in all cells, is an intermediate metabolite of methionine and cysteine metabolism. Hyperhomocysteinemia (HHcy) resulting from an in-born error of metabolism that leads to accumulation of high levels of Hcy, is associated with vascular damage, neu...

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Bibliographic Details
Main Authors: Bhavneet Kaur, Pradeep Kumar Sharma, Barun Chatterjee, Bhawana Bissa, Vasugi Nattarayan, Soundhar Ramasamy, Ajay Bhat, Megha Lal, Sarbani Samaddar, Sourav Banerjee, Soumya Sinha Roy
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell Communication and Signaling
Subjects:
Homocysteine
Hyperhomocysteinemia
CBS
Neuron
Autophagy
Endoplasmic reticulum
Online Access:https://doi.org/10.1186/s12964-023-01288-w

Internet

https://doi.org/10.1186/s12964-023-01288-w

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