Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents.

Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents.

Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase 1 (CPT1) is a rate-limiting enzyme for beta-oxidation of fatt...

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Bibliographic Details
Main Authors: Anne Skøttrup Mørkholt, Michal Krystian Oklinski, Agnete Larsen, Robert Bockermann, Shohreh Issazadeh-Navikas, Jette Goller Kloth Nieland, Tae-Hwan Kwon, Angelique Corthals, Søren Nielsen, John Dirk Vestergaard Nieland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0234493

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https://doi.org/10.1371/journal.pone.0234493

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