A complex regulatory landscape involved in the development of mammalian external genitals

A complex regulatory landscape involved in the development of mammalian external genitals

Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer–enhancer and enhancer–promoter interactions. We used a TAD flanking the mouse HoxD cluste...

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Bibliographic Details
Main Authors: Ana Rita Amândio, Lucille Lopez-Delisle, Christopher Chase Bolt, Bénédicte Mascrez, Denis Duboule
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
hox clusters
TAD
CTCF
chromatin
loop extrusion
enhancers
Online Access:https://elifesciences.org/articles/52962

Internet

https://elifesciences.org/articles/52962

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