The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

Summary: 53BP1 is recruited to chromatin in the vicinity of DNA double-strand breaks (DSBs). We identify the nuclear kinesin, KIF18B, as a 53BP1-interacting protein and define its role in 53BP1-mediated DSB repair. KIF18B is a molecular motor protein involved in destabilizing astral microtubules dur...

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Bibliographic Details
Main Authors: Janna Luessing, Maryam Sakhteh, Naoyuki Sarai, Louise Frizzell, Nikolay Tsanov, Kiefer Olaf Ramberg, Silvia Maretto, Peter Bernard Crowley, Noel Francis Lowndes
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
KIF18B
53BP1
DSB repair
end joining
DDR
Tudor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006823

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721006823

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