Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses

Current monotherapeutic agents fail to restore tolerance to self-antigens in autoimmune individuals without systemic immunosuppression. We hypothesized that a combinatorial drug formulation delivered by a poly-lactic-co-glycolic acid (PLGA) dual-sized microparticle (dMP) system would facilitate tuna...

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Bibliographic Details
Main Authors: Maigan A. Brusko, Joshua M. Stewart, Amanda L. Posgai, Clive H. Wasserfall, Mark A. Atkinson, Todd M. Brusko, Benjamin G. Keselowsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
poly-lactic-co-glycolic acid
microparticle
autoimmunity
immunoregulation
combination therapy
type 1 diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.574447/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.574447/full

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