The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience

The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience

Abstract Recrudescent infections with the human malaria parasite, Plasmodium falciparum, presented traditionally the major setback of artemisinin-based monotherapies. Although the introduction of artemisinin combination therapies (ACT) largely solved the problem, the ability of artemisinin to induce...

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Bibliographic Details
Main Authors: Jaishree Tripathi, Michal Stoklasa, Sourav Nayak, Kay En Low, Erica Qian Hui Lee, Quang Huy Duong Tien, Laurent Rénia, Benoit Malleret, Zbynek Bozdech
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51846-0

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https://doi.org/10.1038/s41467-024-51846-0

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