A facile synthesis of 1,3,4-oxadiazole-based carbamothioate molecules: Antiseizure potential, EEG evaluation and in-silico docking studies

A facile synthesis of 1,3,4-oxadiazole-based carbamothioate molecules: Antiseizure potential, EEG evaluation and in-silico docking studies

In present work, a series of novel structural hybrids of 1,3,4-oxadiazole and carbamothioate was designed by chemical modification of 2-(4-isobutylphenyl)propanoic acid. Target compounds (7a-f) were synthesized in significant yields (84–88 %) by coupling compound (4) with different electrophiles und...

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Bibliographic Details
Main Authors: Nasir Rasool, Zainib Razzaq, Samreen Gul Khan, Sana Javaid, Naheed Akhtar, Sadaf Mahmood, Jørn B. Christensen, Ataf Ali Altaf, Syed Muhammad Muneeb Anjum, Faleh Alqahtani, Abdullah F. AlAsmari, Imran Imran
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Arabian Journal of Chemistry
Subjects:
Epilepsy
6 Hz
PTZ
1,3,4-oxadiazole
Electroencephalogram
Seizure
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223000710

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http://www.sciencedirect.com/science/article/pii/S1878535223000710

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