Biphasic and directed translocation of protein kinase Cα inside cultured endothelial cells before migration

Biphasic and directed translocation of protein kinase Cα inside cultured endothelial cells before migration

Mechanical wounding of an endothelial monolayer induces an immediate Ca2+ wave. Several hours later, the denuded area is covered by endothelial cells (ECs) that migrate to the wound. This migration process is closely related to protein kinase Cα (PKCα), a Ca2+-dependent protein that translocates fro...

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Bibliographic Details
Main Authors: Masataka Arai, Tomoya Shimada, Chihiro Kora, Kazuhiro Nakashima, Toshihiro Sera, Susumu Kudo
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Endothelial cell
Protein kinase Cα
Mechanical injury
Mechanical stimulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817301425

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http://www.sciencedirect.com/science/article/pii/S2405580817301425

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