A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis.

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis.

BACKGROUND:Estimates of current global rabies mortality range from 26,000 to 59,000 deaths per annum. Although pre-exposure prophylaxis using inactivated rabies virus vaccines (IRVs) is effective, it requires two to three doses and is regarded as being too expensive and impractical for inclusion in...

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Bibliographic Details
Main Authors: Chuan Wang, Pawan Dulal, Xiangyang Zhou, Zhiquan Xiang, Hooman Goharriz, Ashley Banyard, Nicky Green, Livia Brunner, Roland Ventura, Nicolas Collin, Simon J Draper, Adrian V S Hill, Rebecca Ashfield, Anthony R Fooks, Hildegund C Ertl, Alexander D Douglas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC6224154?pdf=render

Internet

http://europepmc.org/articles/PMC6224154?pdf=render

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