Transplantation of umbilical cord blood mononuclear cells attenuates the expression of IL-1β via the TLR4/NF-κB pathway in hypoxic-ischemic neonatal rats

Transplantation of umbilical cord blood mononuclear cells attenuates the expression of IL-1β via the TLR4/NF-κB pathway in hypoxic-ischemic neonatal rats

Objective:This study aims to observe the effects of transplantation of umbilical cord blood mononuclear cells (UCBMCs) on the expression of interleukin (IL)-1β and explore the mechanism via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway in hypoxic-ischemic neonatal rats.Metho...

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Bibliographic Details
Main Authors: Meng-Bei Zhang, Chao-Chao Song, Guang-Zu Li, Lan-Fen Chen, Rui Ma, Xiao-He Yu, Ping Gong, Xiao-Li Wang
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of Neurorestoratology
Subjects:
umbilical cord blood mononuclear cell (ucbmc)
hypoxic ischemic brain damage (hibd)
toll-like receptor 4 (tlr4)
nuclear factor-kappa b (nf-κb)
tlr4/nf-κb pathway
neonatal rats
Online Access:https://www.sciopen.com/article/10.26599/JNR.2020.9040015

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https://www.sciopen.com/article/10.26599/JNR.2020.9040015

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