Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication

Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication

The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1, and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including dengue, where it contributes to the establishment of a pro-viral autophagic state. Activation of mTORC2 occurs upon infection w...

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Bibliographic Details
Main Authors: Christoph C. Carter, Fred D. Mast, Jean Paul Olivier, Natasha M. Bourgeois, Alexis Kaushansky, John D. Aitchison
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
mechanistic target of rapamycin (mTOR)
mechanistic target of rapamycin complex 2 (mTORC2)
apoptosis
non-structural protein 5
flavivirus
pathogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.979996/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.979996/full

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