Encapsulating Cas9 into extracellular vesicles by protein myristoylation

Encapsulating Cas9 into extracellular vesicles by protein myristoylation

Abstract CRISPR/Cas9 genome editing is a very promising avenue for the treatment of a variety of genetic diseases. However, it is still very challenging to encapsulate CRISPR/Cas9 machinery for delivery. Protein N‐myristoylation is an irreversible co/post‐translational modification that results in t...

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Bibliographic Details
Main Authors: Joseph Andrew Whitley, Sungjin Kim, Lei Lou, Chenming Ye, Omar Awad Alsaidan, Essilvo Sulejmani, Jingwen Cai, Ellison Gerona Desrochers, Zanna Beharry, Catherine Bowes Rickman, Mikael Klingeborn, Yutao Liu, Zhong‐Ru Xie, Houjian Cai
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of Extracellular Vesicles
Subjects:
CRISPR/Cas9
extracellular vesicles
myristoylation
Src kinase
Online Access:https://doi.org/10.1002/jev2.12196

Internet

https://doi.org/10.1002/jev2.12196

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