Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis

Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis

Context Ferulic acid (FA) has antioxidative and anti-inflammatory effects, and is a promising drug to treat sepsis.Objective To study the therapeutic effect of FA in sepsis-induced acute lung injury (ALI) and its underlying mechanisms.Materials and methods The caecal ligation and puncture (CLP) mano...

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Bibliographic Details
Main Authors: Xianming Tang, Jiqiang Liu, Shuo Yao, Jianfei Zheng, Xun Gong, Bing Xiao
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
MLE-12 cells
cell death
caecal ligation and puncture
ferrostatin-1
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2147549

Internet

https://www.tandfonline.com/doi/10.1080/13880209.2022.2147549

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