Loss of T-Cell Multifunctionality and TCR-Vβ Repertoire Against Epstein-Barr Virus Is Associated With Worse Prognosis and Clinical Parameters in HIV+ Patients

Loss of T-Cell Multifunctionality and TCR-Vβ Repertoire Against Epstein-Barr Virus Is Associated With Worse Prognosis and Clinical Parameters in HIV+ Patients

Epstein-Barr virus (EBV) is an oncogenic virus associated with the development of aggressive and poor-prognosis B-cell lymphomas in patients infected with human immunodeficiency virus (HIV+ patients). The most important risk factors for these malignancies include immune dysfunction, chronic immune a...

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Bibliographic Details
Main Authors: Diana M. Hernández, Sandra Valderrama, Sandra Gualtero, Catalina Hernández, Marcos López, Maria Victoria Herrera, Julio Solano, Susana Fiorentino, Sandra Quijano
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
HIV
EBV
non-Hodgkin B-cell lymphoma
memory T cells
effector T cells
T-cell multifunctionality
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02291/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02291/full

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